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Whipple's Disease: A Case Report.

Marta Batista1, Maria Luis Santos1, Cristina Silva1

  • 1Internal Medicine, Hospital da Senhora da Oliveira, Guimarães, PRT.

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Summary
This summary is machine-generated.

Whipple's disease (WD), a rare bacterial infection, presents with gastrointestinal and joint symptoms. Early diagnosis via biopsy and prompt antibiotic treatment are vital for improved patient outcomes.

Keywords:
chronic abdominal painpersistent diarrheaskin pigmentationunintentional weight losswhipple’s disease

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Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Microbiology

Background:

  • Whipple's disease (WD) is a rare, chronic systemic infection caused by *Tropheryma whipplei*.
  • It primarily affects the small intestine's macrophages, leading to malabsorption and systemic symptoms.
  • Clinical manifestations include diarrhea, weight loss, abdominal pain, and arthralgia, complicating diagnosis.

Observation:

  • A 58-year-old female presented with significant weight loss, hyperpigmentation, nausea, abdominal pain, and diarrhea.
  • Diagnostic workup involved esophagogastroduodenoscopy and colonoscopy with biopsy.
  • Laboratory and microbiological studies confirmed *Tropheryma whipplei* infection.

Findings:

  • Biopsy analysis revealed *Tropheryma whipplei* in the lamina propria's macrophages.
  • The patient's symptoms were consistent with advanced Whipple's disease.
  • Diagnosis was established through integrated clinical, laboratory, and microbiological findings.

Implications:

  • Early diagnosis of Whipple's disease is crucial for effective management and prognosis.
  • Prompt treatment with intravenous and oral antibiotics is essential.
  • This case highlights the importance of considering WD in patients with unexplained gastrointestinal and systemic symptoms.