Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

16
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
16
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

3.8K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.8K
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

651
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
651
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

204
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
204
Lateralization01:28

Lateralization

367
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
367
Lethal Alleles02:41

Lethal Alleles

15.6K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
15.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Pulmonary Arterial Hypertension Therapies on Gas Exchange in Portopulmonary Hypertension.

Chest·2026
Same author

Epidemiological trends of respiratory tract pathogens detected via mPCR in Australian adult patients before COVID-19.

BMC infectious diseases·2024
Same author

Respiratory Infection and Inflammation in Cystic Fibrosis: A Dynamic Interplay among the Host, Microbes, and Environment for the Ages.

International journal of molecular sciences·2023
Same author

Lessons from the contrast dye shortage during COVID-19: A narrative review.

Medicine·2023
Same author

COVID-19: sleeping with both eyes open.

Internal medicine journal·2022
Same author

A case of extreme carboxyhaemoglominemia due to vaping.

Respirology case reports·2022
Same journal

Chronic Expanding Hematoma Complicated by Life Threatening Hemoptysis and Respiratory Arrest-A Case Report.

Respirology case reports·2026
Same journal

Initial Dose Tarlatamab-Associated Tumour Lysis Syndrome in Small Cell Lung Cancer: A Case Report.

Respirology case reports·2026
Same journal

EBUS-Guided Incidental Finding of Pulmonary Vein Thrombosis: A Case Report and Literature Review.

Respirology case reports·2026
Same journal

First Case of Acute Pleural Empyema Caused by <i>Mediterraneibacter gnavus</i>.

Respirology case reports·2026
Same journal

A Case of Disseminated Nocardiosis due to <i>Nocardia otitidiscaviarum</i> With Pulmonary Infection and a Thyroid Abscess.

Respirology case reports·2026
Same journal

Usual Interstitial Pneumonia in a Patient With Celiac Disease: Expanding the Spectrum of Pulmonary Manifestations.

Respirology case reports·2026
See all related articles

Related Experiment Video

Updated: Jul 24, 2025

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection
02:22

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

390

Lane-Hamilton syndrome.

Audrey K Grech1, Christiaan Yu1,2

  • 1Department of Respiratory Medicine Alfred Health Melbourne Victoria Australia.

Respirology Case Reports
|July 7, 2023
PubMed
Summary
This summary is machine-generated.

Lane-Hamilton Syndrome, the co-existence of idiopathic pulmonary hemosiderosis and celiac disease, can present years after celiac diagnosis. Early identification and a strict gluten-free diet are crucial for managing this rare condition.

Keywords:
Lane‐Hamilton syndromeceliac diseasehemoptysisidiopathic pulmonary hemosiderosisimmunosuppression

More Related Videos

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

2.4K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.7K

Related Experiment Videos

Last Updated: Jul 24, 2025

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection
02:22

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

390
Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

2.4K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.7K

Area of Science:

  • Pulmonology
  • Gastroenterology
  • Immunology

Background:

  • Lane-Hamilton Syndrome is a rare condition characterized by the co-existence of idiopathic pulmonary hemosiderosis (IPH) and celiac disease (CD).
  • IPH presents with recurrent hemoptysis, which can be life-threatening.
  • The syndrome's pathogenesis involves an autoimmune response triggered by gluten in genetically susceptible individuals.

Observation:

  • This report details an uncommon case of IPH developing nearly a decade after a CD diagnosis.
  • The patient experienced recurrent, severe hemoptysis despite immunosuppressive therapy due to persistent gluten ingestion.
  • Delayed diagnosis complicated management and treatment efficacy.

Findings:

  • Effective management required high-dose glucocorticoids and mycophenolate mofetil.
  • A strict gluten-free diet is essential for controlling IPH in patients with CD.
  • Identifying Lane-Hamilton Syndrome is critical for appropriate and timely treatment.

Implications:

  • This case underscores the importance of considering IPH in CD patients with unexplained pulmonary symptoms.
  • Long-term adherence to a gluten-free diet is paramount for preventing and managing IPH recurrence.
  • Integrated treatment strategies combining immunosuppression and dietary modifications are vital for improving patient outcomes.