Related Experiment Video
Updated: Jul 24, 2025
06:07
Analyzing Long-Term Electrocardiography Recordings to Detect Arrhythmias in Mice
Published on: May 23, 2021
3.8K
Electrocardiogram analysis in Anderson-Fabry disease: a valuable tool for progressive phenotypic expression tracking
V Parisi1,2, R Baldassarre1,2, V Ferrara3
1Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Frontiers in Cardiovascular Medicine
|July 7, 2023
Summary
Electrocardiogram (ECG) changes correlate with the progression of Anderson-Fabry disease (AFD) cardiac involvement. Specific ECG patterns can now represent different stages of AFD, aiding in disease monitoring.
Area of Science:
- Cardiology
- Genetics
Background:
- Electrocardiogram (ECG) is valuable for detecting cardiac issues in Anderson-Fabry disease (AFD).
- Limited data exists on how ECG alterations relate to AFD progression.
Purpose of the Study:
- To compare ECG abnormalities across different left ventricular hypertrophy (LVH) severity groups in AFD patients.
- To identify ECG patterns indicative of progressive AFD stages.
Main Methods:
- A cross-sectional study of 189 AFD patients from a multicenter cohort.
- Comprehensive analysis of ECG, echocardiography, and clinical data.
- Patients categorized into four groups based on left ventricular (LV) thickness.
Main Results:
- Right bundle branch block (RBBB) prevalence increased with LV thickness, becoming complete in advanced stages (Group D).
- Left anterior fascicular block, LVH criteria, negative T waves, and ST depression were more frequent in advanced AFD.
- Distinct ECG patterns emerged for each LVH severity group, from normal ECGs in mild cases to complete RBBB and QRS fragmentation in severe AFD.
Conclusions:
- ECG is a sensitive tool for identifying and monitoring cardiac involvement in AFD.
- ECG provides insights into the natural history of cardiac changes in AFD.
- Further research is needed to determine if ECG changes correlate with clinical events.
Related Concept Videos
01:29Electrocardiogram
2.5K
An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
2.5K
01:28Electrocardiogram Fundamentals
650
Introduction
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
650
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
38
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
38
01:30Dysrhythmias V: Evaluating Dysrhythmias
42
Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
42