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Drugs for Treatment of Constipation-Predominant IBS01:21

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
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2022 Seoul Consensus on Clinical Practice Guidelines for Functional Constipation.

Young Sin Cho1, Yoo Jin Lee2, Jeong Eun Shin3

  • 1Division of Gastroenterology, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Chungcheongnam-do, Korea.

Journal of Neurogastroenterology and Motility
|July 7, 2023
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Summary

New guidelines offer evidence-based recommendations for diagnosing and managing chronic constipation. This includes evaluating new drugs and conventional laxatives for functional constipation, aiding clinical decisions.

Keywords:
ConstipationDiagnosisGuidelineMeta-analysisTherapeutics

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Area of Science:

  • Gastroenterology
  • Clinical Practice Guidelines

Background:

  • Chronic constipation is a prevalent digestive disorder with diverse symptoms.
  • Objective evaluation tools like the Bristol Stool Form Scale aid diagnosis.
  • Physiological tests are valuable for refractory cases and suspected defecatory disorders.

Purpose of the Study:

  • To revise and update evidence-based guidelines for functional constipation diagnosis and management.
  • To provide recommendations based on systematic reviews and meta-analyses.
  • To inform clinicians and patients on optimal treatment strategies.

Main Methods:

  • Systematic review and meta-analysis of existing literature.
  • Evaluation of pharmacological agents, including novel drugs (lubiprostone, linaclotide) and conventional laxatives.
  • Development of 34 evidence-based recommendations covering definition, epidemiology, diagnosis, and management.

Main Results:

  • The guidelines address the benefits and cautions of various treatment options.
  • Recommendations cover diagnostic criteria and therapeutic approaches for functional constipation.
  • Meta-analysis informed the assessment of pharmacological interventions.

Conclusions:

  • These guidelines provide a comprehensive framework for managing functional constipation.
  • Clinicians and patients can utilize these recommendations for informed decision-making.
  • Updated guidance reflects new evidence on diagnosis and treatment of constipation.