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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
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NEW DATA ON HISTOGENESIS AND HISTOLOGICAL STRUCTURE OF LUNG CANCER.

L Bolgova1, A Shypko1, T Tuganova1

  • 1National Cancer Institute of the Ministry of Health of Ukraine, Kyiv 03022, Ukraine.

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|July 7, 2023
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Summary

This study reveals that lung cancer (LC) exhibits alveolar growth patterns, originating from the basal membrane and progressing centrally. This finding offers new insights into the development of malignant epithelial tumors.

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Area of Science:

  • Oncology
  • Pathology
  • Cancer Research

Background:

  • Lung cancer (LC) is a prevalent malignancy globally, presenting significant challenges in oncology.
  • Understanding the intricate growth patterns of lung cancer is crucial for developing effective therapeutic strategies.

Purpose of the Study:

  • To investigate the histogenesis and histological growth characteristics of lung cancer.
  • To analyze the microscopic features and developmental patterns of various lung cancer subtypes.

Main Methods:

  • Histological analysis of surgical specimens from 81 lung cancer patients.
  • Staining techniques including hematoxylin and eosin (H&E) and Papanicolaou staining.
  • Immunohistochemical analysis using Ki67 and PCNA markers.

Main Results:

  • Alveolar growth was observed in all studied lung cancer types (squamous cell, adenocarcinoma, small cell).
  • Tumor growth initiated from the basal membrane and extended towards the alveolar center.
  • Morphological evidence supported this growth pattern, including tumor spread and central necrosis.

Conclusions:

  • Alveolar growth is a consistent feature across different histological types of lung cancer.
  • This growth pattern is supported by structural, cellular, and degenerative signs.
  • The findings align with general principles of malignant epithelial tumor development.