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Updated: Jul 24, 2025
Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
Published on: March 17, 2020
NEW DATA ON HISTOGENESIS AND HISTOLOGICAL STRUCTURE OF LUNG CANCER
L Bolgova1, A Shypko1, T Tuganova1
1National Cancer Institute of the Ministry of Health of Ukraine, Kyiv 03022, Ukraine.
Background:
Lung cancer (LC) is one of the most common malignant neoplasms in men around the world, which poses a number of important challenges for scientists.
Aim:
To analyze the histogenesis, features of the histological structure, and growth of LC.
Materials And Methods:
The surgical material of 81 patients with LC was studied. Histological preparations were stained with hematoxylin and eosin (H&E) using the Papanicolaou method. Immunohistochemical reactions with monoclonals (Ki67, PCNA) were conducted.
Results:
In histological preparations of all LC types (squamous, adenocarcinoma, and small cell), along with solid growth, tumor growth in the alveoli was determined, which started from the basal membrane and grew toward the alveolus center, as evidenced by the morphological features of growth, tumor spread, and development of necrosis in the center.
Conclusion:
In all the studied histological preparations of LC, tumor growth in the alveoli is noted, which is confirmed by structural and cellular signs and the nature of tumor decay in the alveolus center, which corresponds to the general patterns of development of malignant epithelial tumors.
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