Related Experiment Video
Updated: Jul 24, 2025
Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Epidemiology of mumps, mumps complications, and mumps orchitis in Korea using the National Health Insurance Service
Jung Wan Yoo1, Bum Sik Tae1, Hyun Kyung Chang1
1Department of Urology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
Purpose:
To analyze the presentation of mumps and mumps orchitis using the National Health Insurance Service Database (NHISD).
Materials And Methods:
Using information from the NHISD representing all cases of mumps in Korea, data regarding mumps orchitis were analyzed. The International Classification of Diseases, Tenth Revision, and Clinical Modification codes were used for diagnosis. The incidence estimates of the number of mumps cases were analyzed using the Statistical Analysis System (SAS) software.
Results:
Based on the NHISD, 199,186 people were diagnosed with mumps, and males accounted for 62.3% cases. Teen males accounted for 69,870 cases, the largest number of patients diagnosed with mumps. The annual incidence of mumps increased every year (poisson regression, hazard ratio [HR] 1.026, 95% confidence interval [CI] 1.024-1.027; p<0.025). The risk of mumps was lower in females than that in males (poisson regression, HR 0.594, 95% CI 0.589-0.599; p<0.001). Of the 199,186 patients diagnosed with mumps, 3,872 patients (1.9%) had related complications. Among the mumps complications, the most diagnosed complication was mumps orchitis, which was seen in 41.8% of the males. Mumps orchitis cases accounted for less than 1.5% of the patients with mumps in minors under the age of 20 years and was somewhat higher in 2009 and 2013-2015.
Conclusions:
Among the complications related to mumps, meningitis was most common in females, while orchitis was dominant in males. Mumps orchitis also shows periodic outbreaks but is particularly prevalent in adults, which suggests the potential need for additional vaccination against mumps.
Insights
Mumps primarily affects teen males, with mumps orchitis being a common complication in adult males. Periodic outbreaks occur, suggesting a need for enhanced mumps vaccination strategies.
Area of Science:
- Epidemiology
- Public Health
- Infectious Diseases
Background:
- Mumps is a viral infection with potential complications.
- Mumps orchitis, an inflammation of the testicles, is a significant concern in males.
Purpose of the Study:
- To analyze the epidemiological characteristics of mumps and mumps orchitis in Korea.
- To investigate the incidence and trends of mumps and its complications using national health data.
Main Methods:
- Utilized the National Health Insurance Service Database (NHISD) for comprehensive data on mumps cases in Korea.
- Employed International Classification of Diseases, Tenth Revision, and Clinical Modification codes for diagnosis.
- Analyzed incidence trends using Statistical Analysis System (SAS) software and Poisson regression.
Main Results:
- Identified 199,186 mumps cases, with males (62.3%) and teen males being most affected.
- Observed an annual increase in mumps incidence (HR 1.026) and a higher risk in males compared to females (HR 0.594).
- Mumps orchitis was the most frequent complication in males (41.8%), with higher prevalence in adults and periodic outbreaks noted.
Conclusions:
- Mumps complications differ by sex, with meningitis in females and orchitis predominantly in males.
- Mumps orchitis shows a predilection for adults and exhibits periodic outbreaks.
- Findings suggest a potential need for additional mumps vaccination, particularly for adult males.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:25Statistical Methods for Analyzing Epidemiological Data
01:30Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
01:30Pneumonia III: Complications and Assessment
01:28Acute Pyelonephritis II: Diagnostic Studies and Management