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Updated: Jul 24, 2025
07:27
Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
Published on: October 6, 2016
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Resting state network connectivity alterations in HIV: Parallels with aging.
Brandon J Lew1,2, Marie C McCusker1,3, Jennifer O'Neill4
1Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, Nebraska, USA.
Human Brain Mapping
|July 7, 2023
Summary
HIV infection and aging independently increase brain functional connectivity (FC). People with HIV show further FC increases, suggesting a similar brain network reorganization to aging.
Area of Science:
- Neuroimaging
- Neuroscience
- HIV Research
Background:
- Age-related comorbidities suggest accelerated aging in people with HIV (PWH).
- Resting-state functional magnetic resonance imaging (rs-fMRI) reveals neural changes in PWH.
- The impact of aging on resting-state functional connectivity (FC) in PWH is understudied.
Purpose of the Study:
- Investigate the independent and interactive effects of HIV and aging on brain functional connectivity (FC).
- Examine the relationship between HIV-related cognitive deficits and FC.
- Determine if HIV accelerates brain aging processes.
Main Methods:
- Recruited 86 virally suppressed PWH and 99 controls (aged 22-72).
- Utilized resting-state functional magnetic resonance imaging (rs-fMRI) and a 7-network atlas to analyze FC.
- Employed network-based statistical analyses with a 512-region brain atlas for validation.
Main Results:
- Both aging and HIV independently affected between-network FC.
- Age-related increases in FC were widespread.
- PWH exhibited greater increases in FC than controls, particularly between the default-mode and executive control networks.
Conclusions:
- HIV infection and aging independently increase between-network FC.
- HIV may induce brain network reorganization similar to aging.
- Findings suggest HIV accelerates brain aging through altered functional network interactions.
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