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Updated: Jul 24, 2025

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General Anti-Markovnikov Hydrophosphinylation of Olefins Using Disulfide as the Photocatalyst and a Hydrogen Atom
Guoxiang Zhang1, Hui He2, Xiaoxiao Chen1
1School of Chemistry, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
Abstract:
The photoinduced radical-based hydrophosphinylation suffered from substrate scope limitation due to the highly electrophilic property of the P(O) radical. Herein, we report an efficient catalytic system for the intermolecular anti-Markovnikov hydrophosphinylation of olefins using disulfide as a photocatalyst and also a hydrogen atom shuttle. This metal-free, base-free, and redox-neutral condition allowed the alkenes with diverse electronic properties to proceed with the anti-Markovnikov P-H addition efficiently. A plausible mechanism involving the HAT process between ArS• and P(O)-H was proposed.
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