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Related Concept Videos

Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Hypersensitivities01:30

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Antigens Involved in Adaptive Immunity01:26

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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Related Experiment Video

Updated: Jul 24, 2025

Basophil Activation Test for Allergy Diagnosis
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Updates in food allergen immunotherapy.

Vibha Szafron1, Ruchit Rana2, Sara Anvari1,3

  • 1Baylor College of Medicine, Department of Pediatrics, Division of Immunology, Allergy and Retrovirology.

Current Opinion in Pediatrics
|July 7, 2023
PubMed
Summary

Food allergen immunotherapy (FAIT) offers a new way to treat rising food allergies by inducing desensitization. Different methods like oral, sublingual, and epicutaneous immunotherapy show promise, especially for children.

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Area of Science:

  • Allergy and Immunology
  • Immunotherapy Research
  • Clinical Therapeutics

Background:

  • Food allergies are increasing globally, posing significant health challenges.
  • Current management relies on allergen avoidance and acute reaction treatment, which are not always feasible.
  • Food allergen immunotherapy (FAIT) is an emerging treatment aiming for desensitization and sustained unresponsiveness.

Conclusions:

  • FAIT presents a promising approach to mitigate the impact of food allergies.
  • Current evidence is encouraging for specific allergens and pediatric populations.
  • Further research is required to compare FAIT modalities across different age groups and allergens.