Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cutaneous phototoxicity reactions.

N J Lowe

    The British Journal of Dermatology
    |August 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    This review covers how light-activated chemicals cause skin reactions (phototoxicity) and methods to predict them. It highlights animal models and in vitro tests for screening potential phototoxic agents like psoralens.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Vein imaging laser reduces bruising in bruise-prone botulinum toxin injected patients.

    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology·2016
    Same author

    Dissolving unwanted submental fat.

    The British journal of dermatology·2014
    Same author

    Dispelling the myth: appropriate use of poly-L-lactic acid and clinical considerations.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2006
    Same author

    Light-emitting diode 415 nm in the treatment of inflammatory acne: an open-label, multicentric, pilot investigation.

    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology·2006
    Same author

    Adverse reactions to dermal fillers: a review of European experiences.

    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology·2006
    Same author

    An overview of ultraviolet radiation, sunscreens, and photo-induced dermatoses.

    Dermatologic clinics·2005
    Same journal

    Does loss of chromosome Y in blood contribute to the sex disparity of dermatitis and eczema at older ages?

    The British journal of dermatology·2026
    Same journal

    Soluble CD83 reverses alopecia areata via IDO-mediated Treg cell activation.

    The British journal of dermatology·2026
    Same journal

    Durability of Response to Icotrokinra in Adults With Moderate-to-Severe Plaque Psoriasis: One-Year Results From the Phase 3, Placebo- and Active Comparator-Controlled ICONIC-ADVANCE 1 & ICONIC-ADVANCE 2 Trials.

    The British journal of dermatology·2026
    Same journal

    Clinicopathological features of lymphocytic thrombophilic arteritis and the relationship with livedoid vasculopathy - a case series of 36 patients.

    The British journal of dermatology·2026
    Same journal

    Improving Prognostication for Cutaneous Squamous Cell Carcinoma.

    The British journal of dermatology·2026
    Same journal

    Recurrent and novel GLTP variants in five patients with nonsyndromic epidermal differentiation disorder: phenotypic and genotypic expansion.

    The British journal of dermatology·2026
    See all related articles

    Area of Science:

    • Dermatology
    • Photobiology
    • Toxicology

    Background:

    • Phototoxicity is a non-immunological reaction triggered by light interacting with photoactive chemicals.
    • These chemicals can be exogenous (topical or systemic) or endogenous.
    • Examples include psoralens found in therapeutic agents, perfumes, and cosmetics.

    Purpose of the Study:

    • To review mechanisms of cutaneous phototoxicity.
    • To discuss methods for predicting and ranking phototoxic reactions.
    • To explore various testing strategies for phototoxic agents.

    Main Methods:

    • Animal models: visual evaluation, hairless mouse (skin thickening, polyamine enzymes).
    • In vitro assays: Candida albicans assay, bacterial mutagenicity (e.g., Salmonella typhimurium).

    Related Experiment Videos

  • Human testing: topical or oral administration with UV radiation.

    • Main Results:

    • Animal models show promise in indicating dermal edema and biochemical changes.
    • In vitro bacterial mutagenicity assays offer rapid screening of chemical phototoxicity.
    • Human testing allows direct evaluation of phototoxic reaction intensity.

    Conclusions:

    • Various methods exist for evaluating and predicting cutaneous phototoxicity.
    • Animal and in vitro models provide valuable screening tools.
    • Human testing is crucial for assessing real-world phototoxic responses.