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Updated: Jul 24, 2025
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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
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Noncoding RNAs in atherosclerosis: regulation and therapeutic potential
Luyao Qi1, Jixiang Xing2, Yuesong Yuan3
1Critical Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, 200137, Shanghai, China.
Molecular and Cellular Biochemistry
|July 7, 2023
Summary
Noncoding RNAs (ncRNAs) are key regulators in atherosclerosis development, impacting endothelial and smooth muscle cells. Understanding their roles offers new therapeutic strategies for this cardiovascular disease.
Area of Science:
- Cardiovascular Biology
- Molecular Medicine
- Genetics
Background:
- Atherosclerosis is a leading cause of global mortality, characterized by arterial disease and cellular dysfunction.
- Noncoding RNAs, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), are implicated in cellular processes.
- Dysfunction of endothelial cells and vascular smooth muscle cells is central to atherosclerosis pathogenesis.
Purpose of the Study:
- To review the current research on the regulatory roles of noncoding RNAs in atherosclerosis progression.
- To summarize the therapeutic potential of noncoding RNAs for treating atherosclerosis.
- To provide a comprehensive overview of noncoding RNAs' interventional roles in atherosclerosis.
Main Methods:
- Literature review of recent scientific publications.
- Analysis of studies focusing on noncoding RNA regulation in atherosclerosis.
- Synthesis of findings on therapeutic applications of noncoding RNAs.
Main Results:
- Noncoding RNAs are identified as critical regulators in the development of atherosclerosis.
- Evidence highlights the involvement of ncRNAs in endothelial and vascular smooth muscle cell dysfunction.
- Emerging research indicates significant therapeutic potential for ncRNAs in atherosclerosis treatment.
Conclusions:
- Noncoding RNAs play a pivotal role in the pathogenesis of atherosclerosis.
- Targeting ncRNAs presents promising avenues for novel atherosclerosis therapies.
- Further research into ncRNAs could lead to innovative prevention and treatment strategies for cardiovascular disease.
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