Histological and molecular response of oral cavity tissues to Covid-19

The world is still dealing with Covid-19 waves, and maintaining good oral health has systemic effects on overall health. This review's objective is to identify the main oral manifestations of this illness, its effects on oral tissues at their histological bases, their molecular cell mechanisms, and the relationship issues between Covid-19 outcomes and oral health conditions. The main sources of the review are research articles published from 2000 to 2023. The main used terms in search were Covid-19 oral manifestations, Corona virus and Taste, or Olfaction, Covid and periodontitis, or Oral cavity. the angiotensin-converting enzyme II receptor (ACE2), which serves as a cellular entry point for viral entry into the cell to cause Covid-19 infection, is the target of corona virus attacks on human cells. The destruction of keratinocytes and oral fibroblasts, which is an indication of the virus's direct impact on oral tissues, results in inflammatory reactions in the salivary glands, tongue, and gingiva, which may explain both the loss of taste and the mouth ulceration. Additionally, there is a significant correlation between Covid-19 outcome and periodontitis. This results from the connection between hyperinflammation and poor oral hygiene.