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In Vitro Thrombosis Test for Ventricular Assist Devices
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Music Box-Inspired Semi-Automatic Hematocrit Validation Device.

You-Mao Liao1, Ping-Yeh Chiu2, Yuh-Shiuan Chien1

  • 1Institute of Applied Mechanics, National Taiwan University, Taipei 106, Taiwan.

ACS Sensors
|July 7, 2023
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Summary
This summary is machine-generated.

This study introduces the tFuge, a portable, electricity-free centrifuge for measuring hematocrit (HCT). This device offers accurate cardiovascular disease risk assessment using minimal blood, even in resource-limited settings.

Keywords:
Boycott effectconstant torque mechanismhematocritpoint-of-care testportable centrifuge

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Area of Science:

  • Biomedical Engineering
  • Point-of-Care Diagnostics
  • Cardiovascular Disease Risk Assessment

Background:

  • High hematocrit (HCT) levels are linked to cardiovascular disease risk.
  • Current HCT measurement methods (centrifugation) are often bulky, costly, and require electricity.
  • Accessible HCT monitoring is crucial for early cardiovascular disease diagnosis.

Purpose of the Study:

  • To develop a semi-automatic, portable, and electricity-free device for HCT measurement.
  • To create a cost-effective and user-friendly alternative to traditional centrifuges.
  • To enable rapid HCT assessment at the point-of-care.

Main Methods:

  • Development of the tFuge, a torque-actuated, music-box-inspired semi-automatic centrifuge.
  • Utilizing the Boycott effect for efficient blood cell sedimentation.
  • Employing a constant torque mechanism for consistent operation.
  • Printing calibrated gradient numbers on the rotation disc for direct HCT reading.

Main Results:

  • The tFuge achieved repeatable HCT measurements across diverse users.
  • Demonstrated high linearity between HCT levels and blood cell sedimentation length (R² = 0.99) within a 10-60% HCT range.
  • Completed testing in under 4 minutes using only 10 μL of blood from a finger prick.

Conclusions:

  • The tFuge is a viable, portable, and electricity-free device for HCT measurement.
  • It offers a potential replacement for traditional microhematocrit centrifuges, especially in resource-limited areas.
  • Facilitates accessible cardiovascular disease risk screening through point-of-care HCT testing.