Related Experiment Video
Updated: Jul 24, 2025

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst
Published on: June 8, 2016
Visible-Light-Induced Synthesis of Branched Ethers via Multicomponent Reactions
Nándor Győrfi1,2, Gábor Tasnádi1, Márió Gyuris1
1Servier Research Institute of Medicinal Chemistry, Záhony u 7, 1031 Budapest, Hungary.
Abstract:
The Spin-Center Shift (SCS) elimination is a specific way for the generation of radicals with relevance in synthetic and biochemical pathways. The combination of SCS-mediated radical chemistry and atom-transfer radical addition (ATRA) offers new directions in diversity-oriented chemical synthesis. Herein, we report a photoredox three-component reaction of α-acyloxy-N-heterocycles as radical precursors, styrene derivatives as radical trapping agents, and alcohols as nucleophilic quenchers. The novel radical-polar crossover reaction provides access to a diverse set of branched ethers possessing high structural complexity. The utility of the transformation was also demonstrated by the synthesis of a complex drug derivative and it was easily scalable to the multigram level. The scope and limitations were also explored and a plausible mechanism was proposed.
More Related Videos
07:36Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
06:31Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
Published on: November 27, 2015
Related Concept Videos
Cycloaddition Reactions: MO Requirements for Photochemical Activation
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Radical Substitution: Allylic Bromination
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction
α-Bromination of Carboxylic Acids: Hell–Volhard–Zelinski Reaction