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Updated: Jul 24, 2025

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
Published on: August 30, 2017
Perirhinal cortex is associated with fine-grained discrimination of conceptually confusable objects in Alzheimer's
Aurélien Frick1, Gabriel Besson2, Eric Salmon3
1GIGA-CRC In Vivo Imaging, University of Liège, Liège, Belgium; Psychology and Neuroscience of Cognition Research Unit, University of Liège, Liège, Belgium.
Abstract:
The perirhinal cortex (PrC) stands among the first brain areas to deteriorate in Alzheimer's disease (AD). This study tests to what extent the PrC is involved in representing and discriminating confusable objects based on the conjunction of their perceptual and conceptual features. To this aim, AD patients and control counterparts performed 3 tasks: a naming, a recognition memory, and a conceptual matching task, where we manipulated conceptual and perceptual confusability. A structural MRI of the antero-lateral parahippocampal subregions was obtained for each participant. We found that the sensitivity to conceptual confusability was associated with the left PrC volume in both AD patients and control participants for the recognition memory task, while it was specifically associated with the volume of the left PrC in AD patients for the conceptual matching task. This suggests that a decreased volume of the PrC is related to the ability to disambiguate conceptually confusable items. Therefore, testing recognition memory or conceptual matching of easily conceptually confusable items can provide a potential cognitive marker of PrC atrophy.
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