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Context matters: hPSC-derived microglia thrive in a humanized brain environment in vivo
Jonas Cerneckis1, Yanhong Shi1
1Department of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, 1500 E. Duarte Rd, Duarte, CA 91010, USA.
Cell Stem Cell
|July 7, 2023
Abstract:
It remains challenging to create a physiologically relevant human-brain-like environment that would support maturation of human pluripotent stem cell (hPSC)-derived microglia (hMGs). Schafer et al.1 (Cell, 2023) now develop an in vivo neuroimmune organoid model with mature homeostatic hMGs for the study of brain development and disease.
