Related Experiment Video

Updated: Jul 24, 2025

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
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Progressive multifocal leukoencephalopathy associated with carbamazepine-induced immune dysfunction and recovery

Sarah Perrott1, Qaisar Imran Khan2, Carl E Counsell3

  • 1School of Medicine Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.

BMJ Case Reports
|July 7, 2023
PubMed

Insights

Carbamazepine, an epilepsy drug, was linked to progressive multifocal leukoencephalopathy (PML) in a patient with mild immune dysfunction. Stopping the drug led to PML resolution and immune recovery.

Area of Science:

  • Neuroimmunology
  • Neurology
  • Infectious Diseases

Background:

  • Epilepsy treatment can involve medications with potential immune effects.
  • Progressive multifocal leukoencephalopathy (PML) is a rare, severe demyelinating disease of the central nervous system.
  • Drug-induced immunosuppression is a known risk factor for opportunistic infections like PML.
Keywords:
brain stem / cerebellumdrugs: CNS (not psychiatric)infection (neurology)neurology (drugs and medicines)

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