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[Yellow nail syndrome. A case report with postmortem study]
Toni Bosch Taltavull1, Javier Gimeno Beltrán2, Adrián Puche Gallego2
1Facultad de Medicina, Universitat de les Illes Balears (UIB).
Summary
Yellow nail syndrome (YNS) is a rare condition causing nail discoloration, lung issues, and lymphedema. Autopsy revealed new findings, including mediastinal lymph node and splenic alterations, offering insights into YNS aetiology.
Area of Science:
- Pathology
- Rare Diseases
- Lymphology
Background:
- Yellow nail syndrome (YNS) is a rare disorder characterized by yellowish nails, respiratory problems, and lymphedema.
- The exact cause of YNS remains unknown, but a primary lymphatic vessel malformation is suspected.
- Published autopsy findings in YNS patients are scarce.
Observation:
- This report details autopsy findings in a YNS patient.
- The autopsy revealed previously undocumented alterations in splenic sinusoids.
- Expansion of mediastinal lymph nodes and their sinuses were also observed.
Findings:
- The study identified novel autopsy findings associated with YNS.
- Observed alterations include changes within the splenic sinusoids.
- Mediastinal lymph-node sinus abnormalities were also noted.
Implications:
- These findings may contribute to understanding the underlying pathology of YNS.
- The observed alterations suggest potential links between YNS and broader lymphatic system dysfunction.
- Further research into lymphatic malformations could elucidate YNS aetiology.
