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[Yellow nail syndrome. A case report with postmortem study].

Toni Bosch Taltavull1, Javier Gimeno Beltrán2, Adrián Puche Gallego2

  • 1Facultad de Medicina, Universitat de les Illes Balears (UIB).

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Summary

Yellow nail syndrome (YNS) is a rare condition causing nail discoloration, lung issues, and lymphedema. Autopsy revealed new findings, including mediastinal lymph node and splenic alterations, offering insights into YNS aetiology.

Keywords:
Afectación linfáticaDerrame pleuralLinfangiectasiasLinfedemaLymphangiectasiasLymphatic involvementLymphedemaPleural effusionSíndrome de las uñas amarillasYellow nail syndrome

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Area of Science:

  • Pathology
  • Rare Diseases
  • Lymphology

Background:

  • Yellow nail syndrome (YNS) is a rare disorder characterized by yellowish nails, respiratory problems, and lymphedema.
  • The exact cause of YNS remains unknown, but a primary lymphatic vessel malformation is suspected.
  • Published autopsy findings in YNS patients are scarce.

Observation:

  • This report details autopsy findings in a YNS patient.
  • The autopsy revealed previously undocumented alterations in splenic sinusoids.
  • Expansion of mediastinal lymph nodes and their sinuses were also observed.

Findings:

  • The study identified novel autopsy findings associated with YNS.
  • Observed alterations include changes within the splenic sinusoids.
  • Mediastinal lymph-node sinus abnormalities were also noted.

Implications:

  • These findings may contribute to understanding the underlying pathology of YNS.
  • The observed alterations suggest potential links between YNS and broader lymphatic system dysfunction.
  • Further research into lymphatic malformations could elucidate YNS aetiology.