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Optimal fluid volume for detecting malignancy in serous effusions: a single institution experience
Shaham Beg1, Claudio Zanettini1, Lucio Queiroz2
1Department of Pathology and Laboratory Medicine, New York Presbyterian-Weill Cornell Medicine, New York, New York.
Journal of the American Society of Cytopathology
|July 7, 2023
Summary
Detecting malignancy in serous fluids requires adequate sample volume. A minimum of 70 mL of serous fluid is recommended for optimal cytopathological diagnosis and improved cancer detection rates.
Area of Science:
- Cytopathology
- Oncology
- Fluid analysis
Background:
- Malignant cells in serous fluids indicate advanced cancer, crucial for treatment decisions.
- Optimal sample volume for detecting malignancy in serous fluid is not well-established.
Purpose of the Study:
- To identify the optimal volume of serous fluid for accurate cytopathological diagnosis.
- To enhance malignancy detection rates in serous fluid samples.
Main Methods:
- Analyzed 1597 serous fluid samples from 1134 patients.
- Utilized the International System for Reporting Serous Fluid Cytopathology (ISRSFC) for diagnosis.
- Performed statistical analysis comparing clinicopathologic results across diagnostic groups.
Main Results:
- Malignancy was detected in samples ranging from 5 mL to 5000 mL.
- Higher sample volumes significantly increased malignancy detection rates.
- Optimal volume for overall serous fluid malignancy detection is 70 mL.
Conclusions:
- Increased fluid volume correlates with higher malignancy detection and lower false-negative rates.
- A minimum of 70 mL of serous fluid is recommended for optimal cytopathology.
- Pericardial fluid is an exception, requiring a lower volume due to its characteristics.
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