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Related Experiment Video

Updated: Jul 24, 2025

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy
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Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy

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Nailfold capillaroscopy.

Vanessa Smith1, Claudia Ickinger2, Elvis Hysa3

  • 1Department of Internal Medicine, Ghent University, Ghent, Belgium; Department of Rheumatology, Ghent University Hospital, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium.

Best Practice & Research. Clinical Rheumatology
|July 7, 2023
PubMed
Summary
This summary is machine-generated.

Nailfold capillaroscopy is vital for diagnosing systemic sclerosis (SSc) and monitoring Raynaud's phenomenon. This method detects microcirculation changes, aiding early detection and predicting disease progression in rheumatic conditions.

Keywords:
Connective tissue diseasesEULAR study group on microcirculation in rheumatic diseasesNailfold capillaroscopyRaynaud's phenomenonScleroderma patternSystemic sclerosis

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Area of Science:

  • Rheumatology
  • Microcirculation Imaging
  • Diagnostic Techniques

Background:

  • Nailfold capillaroscopy is a safe, established method for assessing microcirculation.
  • It is crucial for investigating and monitoring Raynaud's phenomenon.
  • The "scleroderma pattern" may indicate systemic sclerosis (SSc).

Purpose of the Study:

  • To highlight practical aspects of videocapillaroscopy for microcirculation assessment.
  • To emphasize standardized terminology and analysis frameworks.
  • To discuss the diagnostic and predictive value of capillaroscopy in rheumatic diseases.

Main Methods:

  • Videocapillaroscopy for image acquisition and analysis.
  • Inclusion of dermoscopy techniques.
  • Application of the European Alliance of Associations for Rheumatology (EULAR) consensus reporting framework.

Main Results:

  • Standardized evaluation using the EULAR framework is paramount for accurate diagnosis.
  • Capillaroscopy is relevant for early diagnosis of SSc.
  • Capillary loss shows predictive value for organ involvement and disease progression.

Conclusions:

  • Nailfold capillaroscopy is essential for diagnosing and monitoring SSc and other rheumatic diseases.
  • Standardized videocapillaroscopy aids in early detection and prognosis.
  • The technique offers insights into microcirculatory changes and disease activity.