Plasma-Derived Nanoclusters for Site-Specific Multimodality Photo/Magnetic Thrombus Theranostics

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Pharmacology

Background:

• Traditional thrombolytic therapies face challenges including poor thrombus penetration, off-target effects, and low bioavailability, limiting their efficacy.
• Precisely controlled and targeted delivery of therapeutics is hypothesized to overcome these limitations.

Purpose of the Study:

• To develop and characterize a multifunctional theranostic platform for enhanced thrombolysis.
• To evaluate the efficacy and safety of the theranostic platform in a preclinical thrombosis model.

Main Methods:

• Development of a biocompatible, fluorescent, and magnetic theranostic platform with multiple targeting capabilities.
• Utilizing near-infrared (NIR) phototherapy and magnetic actuation for remote visualization, guidance, and mechanical therapy.
• Assessment of thrombus reduction and side effects in a mouse model of thrombosis.

Main Results:

• The multimodal theranostic system demonstrated remote magnetic guidance and visualization towards thrombi.
• Magnetic guidance improved nanomedicine penetration into thrombi.
• Thrombosis residues were reduced by approximately 80% with no observed side effects or secondary embolization.

Conclusions:

• The developed theranostic platform offers a promising strategy for overcoming limitations of traditional thrombolysis.
• This approach enables precise, targeted delivery, enhancing thrombolysis progression and lysis rate for time-critical applications.