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Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse
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Imaging cardiac hypertrophy in hypertrophic cardiomyopathy and its differential diagnosis

Lana Rashdan1, James Hodovan, Ahmad Masri

  • 1Hypertrophic Cardiomyopathy Center, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.

Current Opinion in Cardiology
|July 8, 2023
PubMed

Insights

Advanced cardiac imaging is crucial for diagnosing myocardial hypertrophy in hypertrophic cardiomyopathy (HCM) and its mimics. New techniques improve precision, aiding in differentiating conditions like cardiac amyloidosis and Fabry disease for better treatment.

Area of Science:

  • Cardiology
  • Medical Imaging

Background:

  • Myocardial hypertrophy in hypertrophic cardiomyopathy (HCM) requires precise diagnosis.
  • Cardiac myosin inhibitors necessitate accurate etiological assessment.

Approach:

  • Review of advanced imaging techniques for myocardial hypertrophy.
  • Focus on differentiating HCM from phenocopies like cardiac amyloidosis and Fabry disease.
  • Assessment of non-gadolinium-based imaging for myocardial fibrosis.

Key Points:

  • Imaging advances enhance precision, diagnosis, and prognosis prediction.
  • Differentiating athlete's heart from HCM is improved.
  • Noninvasive diagnosis of cardiac amyloidosis is increasingly highlighted.
  • Recent data on Fabry disease and HCM phenocopies are discussed.

Conclusions:

  • Accurate imaging is vital for managing HCM and its phenocopies.
  • The field is rapidly evolving with new therapies under investigation.
Abstract

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