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A multifunctional quinoxaline-based chemosensor for colorimetric detection of Fe3+ and highly selective fluorescence
Mohammad Ali Ebrahimzadeh1, Zahra Hashemi2, Pourya Biparva3
1Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Abstract:
A new dual responsive colorimetric and fluorescent turn-off sensor for Fe3+ and Cu2+ was designed and synthesized based on quinoxaline derivative by a simple procedure reaction. 2,3-bis(6-bromopyridin-2-yl)-6-methoxyquinoxaline (BMQ) was fabricated and characterized using ATR-IR, 13C and 1H NMR, and Mass spectroscopy. The interaction of BMQ with Fe3+ caused a significant color change from colorless to yellow. The sensing complex BMQ-Fe3+ with high selectivity was described to be 1:1 by the molar ratio plot. In this experiment, iron was detected by naked-eye using a recently synthesized ligand (BMQ). This color change was unexpectedly observed in iron-overloaded plasma, which had previously been admitted by AAS (Atomic Absorption Spectroscopy). Normal plasma, however, did not exhibit this color change. Interestingly, Cu2+ ions cause a quench at the local emission around 565 nm. On the other hand, receptor-binding selectivity for Cu2+ over a wide linear concentration range was observed through changes in the emission spectra. BMQ-Cu2+ was characterized to be 1:1 by the Job's plot. The emission intensity of BMQ-Cu2+ complex was balanced within only 1 min. various mineral water samples were analyzed for detecting Cu2+. The results show the great potential of the developed probe BMQ for the sensing of Cu2+ ions in mineral and drinking water samples.
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