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Related Experiment Video

Updated: Jul 24, 2025

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Published on: September 13, 2022

Not So Innocent Indapamide.

Shayan Aziz¹, ², Satyan Rajbhandari¹

¹Diabetes and endocrine department, Chorley and South Ribble District General Hospital, Lancashire Teaching Hospitals.

Journal of Ayub Medical College, Abbottabad : JAMC

|July 9, 2023

Summary

Indapamide, a medication for hypertension, can cause neutropenia and hyponatremia. Stopping the drug led to the patient's blood counts returning to normal within two weeks.

Keywords:

Indapamide; Hyponatremia Neutropenia

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Area of Science:

Nephrology
Pharmacology
Hematology

Background:

Neutropenia and hyponatremia are potential adverse effects of certain medications.
Indapamide is a diuretic commonly prescribed for hypertension.

Purpose of the Study:

To report a rare case of neutropenia and hyponatremia associated with Indapamide use.
To highlight the importance of drug history in diagnosing cytopenias and electrolyte imbalances.

Main Methods:

A case report of a 58-year-old male patient presenting with asymptomatic neutropenia and hyponatremia.
Review of patient's medical history, focusing on recent medication initiation.
Discontinuation of Indapamide and monitoring of blood parameters.

Main Results:

The patient was asymptomatic despite presenting with significant neutropenia and hyponatremia.
No other cause for these abnormalities was identified.
Blood counts normalized within two weeks after discontinuing Indapamide.

Conclusions:

Indapamide can rarely cause severe hematological side effects like neutropenia and leukopenia, in addition to its known effect of hyponatremia.
Discontinuation of the offending drug is an effective management strategy.
Clinicians should consider Indapamide as a potential cause for unexplained neutropenia and hyponatremia.