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Updated: Jul 24, 2025

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
Published on: January 12, 2020
[Regulatory effect of NF-κB on prostatic hyperplasia: Progress in researches]
Kai-Yue Wang1,2,3,4, Jian-Hui Wu1,2,3
1Department of Pharmacology and Toxicology, Shanghai Institute for Biomedical and Pharmaceutical Technologies / National Evaluation Center for Toxicology of Fertility Regulation Drugs, Shanghai 200032, China.
Abstract:
Benign prostatic hyperplasia (BPH) is a chronic disease, and its exact pathogenesis is not fully clear. Nuclear factor-kappa B (NF-κB), a regulatory factor that can specifically bind target genes and mediate their transcription and expression, is characterized by wide distribution and multiple functions and gradually becoming a hotspot in studies of abnormal cell proliferation-associated diseases and inflammatory diseases. Recent studies have shown that NF-κB is involved in the growth and development of hormone-dependent organs, such as the prostate, by regulating inflammatory response, disturbing endogenous hormone levels and interfering with cell apoptosis. However, few reports are seen on the relationship between NF-κB signaling pathways and BPH. This review outlines the activation of NF-κB and its regulatory pathways in BPH, expecting to provide some reference for the prevention and treatment of BPH.
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