Annular and acral/facial dyskeratotic paraneoplastic disorders

Area of Science:

• Dermatology
• Oncology
• Internal Medicine

Background:

• Paraneoplastic dermatoses are inflammatory skin conditions associated with internal malignancies.
• These disorders are not direct precursors, extensions, or metastases of the cancer.
• Four classical entities are recognized: erythema annulare centrifugum, erythema gyratum repens, acrokeratosis paraneoplastic (Bazex syndrome), and tripe palms.

Purpose of the Study:

• To review the classical entities of annular and acral/facial dyskeratotic paraneoplastic disorders.
• To discuss their associated etiopathogenesis and differential diagnoses.
• To highlight their varied presentations, from classical to subtle disease.

Main Methods:

• Literature review of annular and acral/facial dyskeratotic paraneoplastic disorders.
• Discussion of associated conditions and diagnostic considerations.
• Analysis of clinical presentations and etiological factors.

Main Results:

• Detailed description of erythema annulare centrifugum and erythema gyratum repens (gyrate entities).
• Detailed description of acrokeratosis paraneoplastic (Bazex syndrome) and tripe palms (acral/facial dyskeratotic entities).
• Emphasis on the potential for these conditions to occur with other etiopathogeneses and present atypically.

Conclusions:

• Annular and acral/facial dyskeratotic paraneoplastic disorders represent distinct dermatoses linked to underlying cancers.
• Understanding these entities and their potential variations is crucial for accurate diagnosis and patient management.
• Differential diagnosis is essential, considering both classical and atypical presentations.