Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Parkinson's disease: a genetic study.

M E Alonso, E Otero, R D'Regules

    The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
    |August 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Seasonal shifts in the presence of pathogenic leptospires, Escherichia coli, and physicochemical properties in coastal rivers and streams of Puerto Rico.

    Journal of environmental quality·2020
    Same author

    Relationships between eye fluids and blood values after exercise in lidia cattle: mineral parameters.

    Polish journal of veterinary sciences·2019
    Same author

    Ultralow-temperature device dedicated to soft X-ray magnetic circular dichroism experiments.

    Journal of synchrotron radiation·2018
    Same author

    Evolution of the corpus luteum volume determined ultrasonographically and its relation to the plasma progesterone concentration after artificial insemination in pregnant and non-pregnant dairy cows.

    Veterinary research communications·2017
    Same author

    Versatile variable temperature insert at the DEIMOS beamline for in situ electrical transport measurements.

    Journal of synchrotron radiation·2016
    Same author

    Anti-predator behaviour of adult red-legged partridge (Alectoris rufa) tutors improves the defensive responses of farm-reared broods.

    British poultry science·2016

    Parkinson's Disease may have a significant genetic component, especially in early-onset cases. This study found a higher frequency of affected relatives in early-onset Parkinson's patients, supporting genetic susceptibility theories.

    Area of Science:

    • Neurology
    • Genetics
    • Epidemiology

    Background:

    • Parkinson's Disease (PD) is a complex neurodegenerative disorder.
    • The etiology of PD is thought to involve both genetic and environmental factors.
    • Previous research suggests heterogeneity within PD subtypes.

    Purpose of the Study:

    • To investigate the frequency of familial Parkinson's Disease in a patient cohort.
    • To determine if genetic load differs among PD subtypes.
    • To test Barbeau and Pourcher's hypothesis on PD heterogeneity.

    Main Methods:

    • A cohort of 122 Parkinson's Disease patients was analyzed.
    • Family history of Parkinson's Disease in first-degree relatives was assessed.
    • Patients were classified into subtypes: post-encephalic, symptomatic, and idiopathic.

    Related Experiment Videos

    Main Results:

    • Idiopathic Parkinson's Disease constituted 86% of the cohort.
    • Early-onset idiopathic PD (16.1% of idiopathic group) showed a 23.5% positive family history.
    • Familial essential tremor-related Parkinsonism was observed in 4.7% of patients.

    Conclusions:

    • Parkinson's Disease is likely a heterogeneous condition.
    • Early-onset Parkinson's Disease subtypes exhibit significant genetic susceptibility.
    • Findings support the hypothesis of genetic factors influencing specific PD subtypes.