Related Experiment Video

Updated: Jul 24, 2025

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.3K

Cardiac fludeoxyglucose-18 positron emission tomography in genotype-positive arrhythmogenic cardiomyopathy

Raquel Neves1, Andrew S Tseng2, Ramin Garmany3

  • 1Department of Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory), Mayo Clinic, Rochester, MN, USA.

International Journal of Cardiology
|July 9, 2023
PubMed

Insights

Abnormal myocardial fluorodeoxyglucose (FDG) uptake is common in genetic arrhythmogenic cardiomyopathy (ACM) patients. This finding suggests a significant role for myocardial inflammation in ACM, warranting further investigation with FDG PET scans.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Genetics

Background:

  • Myocardial inflammation is a key factor in arrhythmogenic cardiomyopathy (ACM) pathogenesis.
  • Genetic ACM and inflammatory cardiomyopathy can present with overlapping symptoms.
  • Cardiac fluorodeoxyglucose (FDG) positron emission tomography (PET) findings in ACM are not well-defined.

Purpose of the Study:

  • To investigate the cardiac FDG PET findings in patients with genetically confirmed arrhythmogenic cardiomyopathy.
  • To determine the prevalence and patterns of abnormal myocardial FDG uptake in this patient cohort.

Main Methods:

  • Retrospective analysis of genotype-positive ACM patients from the Mayo Clinic ACM registry.
  • Inclusion criteria: patients who underwent cardiac FDG PET scan.
  • Data extraction included clinical information and FDG PET scan results.

Main Results:

  • Twelve out of 323 (4%) genotype-positive ACM patients underwent cardiac FDG PET.
  • Fifty percent (6/12) of these patients showed abnormal myocardial FDG uptake.
  • Abnormal uptake patterns included diffuse, focal, and patchy patterns, with LMNA-positive patients showing a higher proportion of positive scans.

Conclusions:

  • Abnormal myocardial FDG uptake is frequently observed in genetic ACM patients.
  • These findings reinforce the involvement of myocardial inflammation in the pathophysiology of ACM.
  • Further research is necessary to establish the utility of FDG PET in ACM diagnosis, management, and understanding inflammation's role.
Abstract

Keywords:
Arrhythmogenic cardiomyopathyGenetic testingGeneticsInflammation

More Related Videos

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

3.8K
Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT10:02

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

Published on: May 2, 2012

18.4K

Related Concept Videos

Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
12
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
19
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
11
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
16
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.3K
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
45