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Parameters associated with improvement of systolic function in patients with heart failure

Liv Borum Schöps1,2,3, Morten Sengeløv4,2, Daniel Modin4,2

  • 1Department of Cardiology, Herlev and Gentofte Hospital, Hellerup, Denmark liv.schoeps@hotmail.com.

Heart (British Cardiac Society)
|July 9, 2023
PubMed

Insights

Most heart failure patients improved systolic function with treatment. Key echocardiographic measures and fewer comorbidities like diabetes predicted better left ventricular ejection fraction (LVEF) improvement and lower mortality risk.

Area of Science:

  • Cardiology
  • Heart Failure Research
  • Echocardiography

Background:

  • Heart failure with reduced ejection fraction (HFrEF) affects millions globally.
  • Improving systolic function is a key treatment goal in HFrEF.
  • Identifying predictors of systolic function improvement can optimize patient management.

Purpose of the Study:

  • To identify clinical and echocardiographic parameters associated with improved systolic function in HFrEF outpatients.
  • To explore the relationship between left ventricular ejection fraction (LVEF) improvement and mortality.

Main Methods:

  • Retrospective analysis of 686 HFrEF patients' echocardiograms from Gentofte Hospital.
  • Linear regression used to assess parameters linked to LVEF improvement.
  • Cox regression analyzed survival in relation to LVEF improvement.

Main Results:

  • 81.5% of patients showed improved systolic function (Δ LVEF >0%); 14.6% were super responders (Δ LVEF >20%).
  • LVEF improvement associated with better global longitudinal strain, higher tricuspid annular plane systolic excursion, smaller LV dimensions, lower E/A ratio, higher heart rate, and absence of ischemic cardiomyopathy and diabetes.
  • Higher LVEF improvement correlated with significantly lower mortality risk.

Conclusions:

  • The majority of HFrEF outpatients experienced improved systolic function with treatment.
  • Echocardiographic measures and comorbidities independently predicted LVEF improvement.
  • Greater LVEF improvement was significantly linked to reduced mortality.
Abstract

Keywords:
echocardiographyheart failureheart failure, systolic

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