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Arterial Stiffness in Patients with Bipolar Disorder

Aslı Kazgan Kılıçaslan1, Burcu Sırlıer Emir2, Sevler Yildiz3

  • 1Department of Psychiatry, University of Bozok, Yozgat, Turkey.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
|July 10, 2023
PubMed

Insights

Patients with bipolar disorder (BD) show increased arterial stiffness, a potential cardiovascular disease (CVD) risk factor. Further research is needed to understand the role of medications and BD itself in arterial health.

Area of Science:

  • Cardiology
  • Psychiatry
  • Vascular Biology

Background:

  • Bipolar disorder (BD) is recognized as an inflammatory and metabolic condition.
  • Both BD and its treatments may influence cardiovascular disease (CVD) risk.
  • Arterial stiffness is a key indicator of vascular health and a predictor of CVD.

Purpose of the Study:

  • To investigate arterial stiffness in patients with bipolar disorder (BD).
  • To compare arterial stiffness parameters between BD patients and healthy controls.
  • To explore correlations between medication dosage and arterial stiffness in BD patients.

Main Methods:

  • Study included 39 patients with BD type I in remission and 39 healthy controls.
  • Carotid and femoral artery intima-media thickness (IMT) and arterial thickness were measured using Doppler ultrasonography.
  • Elastic modulus and compliance were calculated as measures of arterial stiffness.

Main Results:

  • Carotid artery elastic modulus was significantly higher in BD patients compared to controls (p=0.015).
  • While IMT was greater in BD patients, the difference was not statistically significant.
  • Positive correlations were found between chlorpromazine and lithium equivalent doses and specific arterial stiffness parameters.

Conclusions:

  • Arterial stiffness may be a relevant factor for CVD risk in BD patients.
  • Further studies are required to differentiate between BD-specific effects and medication impacts on arterial health.
  • The potential arterial protective effects of mood stabilizers warrant further investigation.
Abstract

Keywords:
Arterial stiffnessBipolar disorderCardiovascular risksCarotid intima-media thicknessElastic modulusFemoral artery

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