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Related Experiment Videos

Benign and malignant thyroid nodules after neck irradiation.

M Fjälling, L E Tisell, S Carlsson

    Cancer
    |September 15, 1986
    PubMed
    Summary

    Radiation exposure from x-rays for cervical tuberculous adenitis increases the risk of developing thyroid nodules, both benign and malignant. This elevated risk persists throughout life, underscoring the long-term effects of radiation therapy.

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    The T -786C, G894T, and Intron 4 VNTR (4a/b) Polymorphisms of the Endothelial Nitric Oxide Synthase Gene in Prostate Cancer Cases.

    Genetika·2016

    Area of Science:

    • Endocrinology
    • Oncology
    • Radiology

    Background:

    • Cervical tuberculous adenitis treatment often involves radiation therapy.
    • Long-term effects of radiation exposure on thyroid health are a significant concern.

    Purpose of the Study:

    • To investigate the long-term incidence of thyroid nodules after radiation treatment for cervical tuberculous adenitis.
    • To determine the correlation between radiation dose and the development of benign and malignant thyroid nodules.

    Main Methods:

    • Retrospective examination of 444 individuals treated with x-rays for cervical tuberculous adenitis.
    • Analysis of surgical outcomes for thyroid nodules, differentiating between benign and malignant cases.
    • Correlation analysis between radiation dosage (0.40-50.90 Gy) and nodule development.

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    Main Results:

    • 101 subjects developed thyroid nodules (25 carcinoma, 76 benign).
    • A positive correlation was observed between absorbed radiation dose and the probability of developing both benign and malignant thyroid nodules, even at doses ≥20 Gy.
    • Median latency for carcinoma was 40 years; risk persists lifelong.
    • Female-to-male ratio for benign nodules was 2.9:1 in irradiated populations.

    Conclusions:

    • Radiation therapy for cervical tuberculous adenitis significantly increases the risk of developing thyroid nodules.
    • The risk of thyroid cancer and benign nodules is dose-dependent and long-lasting.
    • While radiation exposure impacts both sexes, benign nodule development shows a higher female predilection.