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Association of GSDMD with microvascular-ischemia reperfusion injury after ST-elevation myocardial infarction

Wenjing Sun1,2, Chunqiu Wang3, Shihua Cui4

  • 1Department of Cardiology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in Cardiovascular Medicine
|July 10, 2023
PubMed
Abstract

Insights

High gasdermin D (GSDMD) levels in ST-elevation myocardial infarction (STEMI) patients correlate with microvascular injury and predict major adverse cardiac events (MACE). Further research is needed to explore therapeutic implications.

Area of Science:

  • Cardiology
  • Molecular Medicine
  • Biomarker Research

Background:

  • Gasdermin D (GSDMD) role in ST-elevation myocardial infarction (STEMI) prognosis is largely unknown.
  • Understanding GSDMD's impact on cardiac injury and outcomes is crucial for STEMI management.

Purpose of the Study:

  • To investigate the association between GSDMD levels and microvascular injury, infarction size (IS), left ventricular ejection fraction (LVEF), and major adverse cardiac events (MACE).
  • To evaluate GSDMD as a prognostic marker in STEMI patients undergoing primary percutaneous coronary intervention (pPCI).

Main Methods:

  • Retrospective analysis of 120 STEMI patients treated with pPCI.
  • Serum GSDMD assessment and cardiac magnetic resonance (CMR) imaging performed within 48 hours and at one-year follow-up.

Main Results:

  • Elevated GSDMD concentrations (≥ median 13 ng/L) were linked to increased microvascular obstruction and intramyocardial hemorrhage (IMH).
  • Higher GSDMD levels correlated with reduced LVEF, larger IS in acute and chronic phases, and increased left ventricular volumes.
  • GSDMD levels ≥ median were associated with a higher incidence of MACE.

Conclusions:

  • High GSDMD concentrations in STEMI patients are significantly associated with microvascular injury, including MVO and IMH.
  • GSDMD emerges as a potent predictor of MACE in STEMI.
  • Further investigation is warranted to elucidate the therapeutic implications of GSDMD in STEMI management.
Keywords:
GSDMDIMHMVOST-segment elevation myocardial infarctionmagnetic resonance imagingmicrovascular dysfunction

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