Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

23
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
23
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

16
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
16
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

18
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
18
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

18
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
18
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

32
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
32
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

11
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
11

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Spatiotemporal Patterns and Environmental Effects of Pelagic Communities in the Northwest Pacific Ocean Based on Sound Scattering Layer Descriptors.

Ecology and evolution·2026
Same author

Exploring perceptions of data risks in AI-enabled nursing research: A qualitative study.

Digital health·2026
Same author

Endometrial Cancer of the Uterine Isthmus: A Cohort Study on Clinicopathological Features and Prognosis.

Cancer medicine·2026
Same author

Assessing the Alignment of Long-Term Care Insurance Benefits and Service Provision: Evidence from Shandong, China and Implications for Implementation Risk.

Risk management and healthcare policy·2026
Same author

Data from the Researcher Mental Health Observatory STAIRCASE Survey.

Journal of open psychology data·2026
Same author

SGLT2 inhibitor dapagliflozin treats heart failure with preserved ejection fraction via the SIRT1/PGC-1α pathway.

Acta biochimica et biophysica Sinica·2026

Related Experiment Video

Updated: Jul 24, 2025

Author Spotlight: Effect of Left Atrial Ligation on Avian Embryonic Hearts and HLHS Implications
04:37

Author Spotlight: Effect of Left Atrial Ligation on Avian Embryonic Hearts and HLHS Implications

Published on: June 16, 2023

1.1K

Atrial standstill associated with lamin A/C mutation: A case report.

Yujiao Zhang1, Yong Zhang1, Manyi Ren1

  • 1Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.

SAGE Open Medical Case Reports
|July 10, 2023
PubMed
Summary

This case report highlights atrial standstill, a rare heart rhythm disorder, as a cause of arterial embolism. Genetic testing identified a mutation in the LMNA gene in affected family members.

Keywords:
Arterial embolismatrial standstillcardiologylamin A/C mutationleft bundle branch area pacing

More Related Videos

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation
09:17

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation

Published on: July 29, 2011

14.8K
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.7K

Related Experiment Videos

Last Updated: Jul 24, 2025

Author Spotlight: Effect of Left Atrial Ligation on Avian Embryonic Hearts and HLHS Implications
04:37

Author Spotlight: Effect of Left Atrial Ligation on Avian Embryonic Hearts and HLHS Implications

Published on: June 16, 2023

1.1K
High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation
09:17

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation

Published on: July 29, 2011

14.8K
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.7K

Area of Science:

  • Cardiology
  • Genetics
  • Electrophysiology

Background:

  • Atrial standstill is a rare arrhythmogenic condition.
  • Arterial embolism can manifest in multiple sites, posing diagnostic challenges.

Observation:

  • A 46-year-old woman presented with widespread arterial emboli.
  • Transthoracic echocardiography and electrophysiological studies revealed atrial standstill as the cause.
  • Family investigation identified similar symptoms in her brother and sister.

Findings:

  • Genetic testing revealed a frameshift double-G insertion mutation (c.1567) in the LMNA gene in all three affected individuals.
  • This mutation is associated with familial atrial standstill and arterial embolism.

Implications:

  • Highlights the importance of considering familial atrial standstill in patients with multiple arterial emboli.
  • Suggests LMNA gene mutations as a potential cause of inherited atrial standstill.
  • Demonstrates successful management with anticoagulation and pacing.