Related Experiment Video
Updated: Jul 24, 2025

Author Spotlight: Effect of Left Atrial Ligation on Avian Embryonic Hearts and HLHS Implications
Published on: June 16, 2023
Atrial standstill associated with lamin A/C mutation: A case report
Yujiao Zhang1, Yong Zhang1, Manyi Ren1
1Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
This case report highlights atrial standstill, a rare heart rhythm disorder, as a cause of arterial embolism. Genetic testing identified a mutation in the LMNA gene in affected family members.
Area of Science:
- Cardiology
- Genetics
- Electrophysiology
Background:
- Atrial standstill is a rare arrhythmogenic condition.
- Arterial embolism can manifest in multiple sites, posing diagnostic challenges.
Observation:
- A 46-year-old woman presented with widespread arterial emboli.
- Transthoracic echocardiography and electrophysiological studies revealed atrial standstill as the cause.
- Family investigation identified similar symptoms in her brother and sister.
Findings:
- Genetic testing revealed a frameshift double-G insertion mutation (c.1567) in the LMNA gene in all three affected individuals.
- This mutation is associated with familial atrial standstill and arterial embolism.
Implications:
- Highlights the importance of considering familial atrial standstill in patients with multiple arterial emboli.
- Suggests LMNA gene mutations as a potential cause of inherited atrial standstill.
- Demonstrates successful management with anticoagulation and pacing.
More Related Videos
09:17High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation
Published on: July 29, 2011
08:10Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
Related Concept Videos
Mitral Stenosis II: Clinical features and Diagnostic Tests
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Mitral Stenosis I: Introduction
Mitral Regurgitation I: Introduction
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Cardiomyopathy II: Dilated Cardiomyopathy