Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HeyJay! A corpus of atypical speech for spoken language understanding and automatic speech recognition.

Scientific data·2026
Same author

Stable speech BCI performance during slow progression of ALS: A longitudinal ECoG study.

Research square·2026
Same author

Implanted brain-computer interface functionality during nighttime in late-stage amyotrophic lateral sclerosis.

Scientific reports·2026
Same author

ALSUntangled #82: N-acetylcysteine.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026
Same author

Initial experience with the precision neuroscience Layer 7 micro-electrocorticography interface for real-time intraoperative neural decoding.

Neurosurgical focus·2026
Same author

Autonomous multisensory enhancement of a visual neuroprosthesis for navigation: technical proof-of-concept with simulated prosthetic vision and single-subject case study of a visual prosthesis user.

Journal of neural engineering·2026
Same journal

Predicting Chemotherapy Response from Staging Laparoscopy Images.

medRxiv : the preprint server for health sciences·2026
Same journal

Development and External Validation of a Machine Learning Model for 10-Year Ischemic Stroke Risk Prediction in Diverse Populations.

medRxiv : the preprint server for health sciences·2026
Same journal

MCH-Guard: Multimodal Machine Learning Framework for Risk Stratification of Cerebral Microhemorrhage Risk in the Alzheimer's Disease Neuroimaging Initiative.

medRxiv : the preprint server for health sciences·2026
Same journal

Genetic and maternal environmental contributions to estimated fetal weight at 20 weeks gestation compared with birthweight.

medRxiv : the preprint server for health sciences·2026
Same journal

Better immediate declarative memory is associated with forgetting during locomotor adaptation in chronic stroke and in older adults.

medRxiv : the preprint server for health sciences·2026
Same journal

An empirical Bayes framework for burden and dispersion association tests helps prioritize rare variants associated with Alzheimer's disease.

medRxiv : the preprint server for health sciences·2026
See all related articles

Related Experiment Video

Updated: Jul 24, 2025

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS
12:43

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

Published on: February 21, 2011

34.9K

Online speech synthesis using a chronically implanted brain-computer interface in an individual with ALS.

Miguel Angrick1, Shiyu Luo2, Qinwan Rabbani3

  • 1Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Medrxiv : the Preprint Server for Health Sciences
|July 10, 2023
PubMed
Summary
This summary is machine-generated.

This study demonstrates a brain-computer interface (BCI) that synthesizes intelligible speech in real-time for individuals with amyotrophic lateral sclerosis (ALS). This BCI allows people with speech impairments to communicate using their own voice profile.

More Related Videos

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
10:15

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

Published on: July 2, 2013

17.9K
Brain-Computer Interface-controlled Upper Limb Robotic System for Enhancing Daily Activities in Stroke Patients
06:11

Brain-Computer Interface-controlled Upper Limb Robotic System for Enhancing Daily Activities in Stroke Patients

Published on: April 18, 2025

517

Related Experiment Videos

Last Updated: Jul 24, 2025

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS
12:43

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

Published on: February 21, 2011

34.9K
Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
10:15

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

Published on: July 2, 2013

17.9K
Brain-Computer Interface-controlled Upper Limb Robotic System for Enhancing Daily Activities in Stroke Patients
06:11

Brain-Computer Interface-controlled Upper Limb Robotic System for Enhancing Daily Activities in Stroke Patients

Published on: April 18, 2025

517

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Speech Synthesis

Background:

  • Intracranial electrodes can reconstruct speech from brain activity, but typically rely on retrospective analysis.
  • Previous research involved temporary implants in individuals without speech impairments.
  • Amyotrophic lateral sclerosis (ALS) causes progressive dysarthria, severely impacting communication.

Approach:

  • Developed and tested a chronically implanted brain-computer interface (BCI) in a clinical trial participant with ALS.
  • The BCI performed online synthesis of intelligible words from a 6-keyword vocabulary.
  • Focused on real-time speech generation for communication.

Key Points:

  • Achieved reliable, online synthesis of intelligible words using a chronically implanted BCI.
  • Demonstrated that a participant with ALS could freely choose and synthesize spoken commands.
  • The synthesized speech preserved the participant's unique voice profile.

Conclusions:

  • This research marks the first successful use of a chronically implanted BCI for real-time speech synthesis in an individual with ALS.
  • The BCI provides a reliable method for restoring communication for individuals with severe speech impairments.
  • Future applications may extend to broader communication needs for patients with neurological disorders affecting speech.