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Compensation between FOXP transcription factors maintains proper striatal function.
Newaz I Ahmed1,2, Nitin Khandelwal1,2, Ashley G Anderson1,3,4
1Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390-9111, USA.
Biorxiv : the Preprint Server for Biology
|July 10, 2023
Summary
Loss of Foxp1 and Foxp2 in dopamine receptor 1 (D1) spiny projection neurons (SPNs) impairs motor and social behaviors. Restoring Foxp1 function ameliorated these deficits, revealing complementary roles in neurodevelopment.
Area of Science:
- Neuroscience
- Genetics
- Developmental Biology
Background:
- Spiny projection neurons (SPNs) in the striatum are crucial for motor control and reward processing.
- Mutations in transcription factors within SPNs are linked to neurodevelopmental disorders (NDDs).
- Foxp1 and Foxp2 are paralogous transcription factors expressed in D1-SPNs, with known links to NDDs.
Conclusions:
- Foxp1 and Foxp2 have complementary roles in D1-SPNs.
- These transcription factors are critical for normal motor and social behavior.
- Deficits caused by Foxp1/Foxp2 loss can be rescued by restoring Foxp1 expression.
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