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Related Experiment Video

Updated: Jul 24, 2025

A Chromatin Assay for Human Brain Tissue

A Chromatin Assay for Human Brain Tissue

Published on: March 21, 2008

Single-cell multiplex chromatin and RNA interactions in aging human brain.

Xingzhao Wen¹, Zhifei Luo², Wenxin Zhao²

¹Program in Bioinformatics and Systems Biology, University of California San Diego, La Jolla, CA 92093, USA.

Biorxiv : the Preprint Server for Biology

|July 10, 2023

Summary

New MUSIC technique maps chromatin interactions, gene expression, and RNA-chromatin links in single cells. Older cells with Alzheimer's show fewer short-range chromatin interactions.

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Last Updated: Jul 24, 2025

A Chromatin Assay for Human Brain Tissue

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Published on: March 21, 2008

Neuronal Nuclei Isolation from Human Postmortem Brain Tissue

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Published on: October 1, 2008

Gentle Isolation of Nuclei from the Brain Tissue of Adult African Turquoise Killifish, a Naturally Short-Lived Model for Aging Research

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Published on: August 9, 2022

Area of Science:

Genomics
Molecular Biology
Neuroscience

Background:

Chromatin complexes are dynamically organized, involving multiplex interactions and chromatin-associated RNA (caRNA).
Chromatin composition varies during cellular differentiation and aging, showing heterogeneity in single cells.

Conclusions:

MUSIC is a powerful tool for dissecting chromatin architecture and transcription at cellular resolution in complex tissues.
The study highlights the link between chromatin interaction patterns, cellular aging, and Alzheimer's pathology.
MUSIC reveals cell-type-specific regulatory mechanisms involving cis eQTLs and provides insights into X chromosome organization in female brain cells.