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Updated: Jul 24, 2025

Using the E1A Minigene Tool to Study mRNA Splicing Changes
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Using the E1A Minigene Tool to Study mRNA Splicing Changes

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Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response

Carolyn Jablonowski, Waise Quarni, Shivendra Singh

    Biorxiv : the Preprint Server for Biology
    |July 10, 2023
    PubMed

    Insights

    Jumonji Domain Containing 6 (JMJD6) connects pre-mRNA splicing and metabolism in MYC-driven cancers. Targeting JMJD6 may offer a new therapeutic strategy for neuroblastoma by impacting glutamine metabolism.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Metabolism

    Background:

    • MYC-driven cancers exhibit dysregulated pre-mRNA splicing and metabolism.
    • Therapeutic strategies targeting these processes are under investigation.
    • The interplay between splicing and metabolism under oncogenic stress is unclear.

    Conclusions:

    • JMJD6 orchestrates a cancer-promoting metabolic program linked to alternative pre-mRNA splicing.
    • Targeting JMJD6 presents a potential therapeutic strategy for MYC-driven cancers, particularly neuroblastoma.

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