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Related Experiment Video

Updated: Jul 24, 2025

Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat

Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat

Published on: October 19, 2011

Inserting a Neuropixels probe into awake monkey cortex: two probes, two methods.

Tomoyuki Namima^1,2, Erin Kempkes¹, Bob Smith³

¹Department of Biological Structure and Washington National Primate Research Center, University of Washington, Seattle, WA 98195, USA.

Biorxiv : the Preprint Server for Biology

|July 10, 2023

Summary

This summary is machine-generated.

Researchers developed novel methods for inserting Neuropixels probes into primate brains. These techniques overcome challenges with the thick primate dura, enabling stable, long-term neurophysiological recordings in awake monkeys.

Keywords:

Nonhuman primate neurophysiology chronic recording chamber high-density silicon probe multi-contact linear probes

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Last Updated: Jul 24, 2025

Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat

Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat

Published on: October 19, 2011

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

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Published on: March 4, 2012

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

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Published on: June 13, 2017

Area of Science:

Neuroscience
Primate Physiology
Neurotechnology

Background:

Neuropixels probes are crucial for rodent neurophysiology but pose insertion challenges in primates due to thicker dura.
Existing methods are insufficient for reliable acute insertion of Neuropixels probes into the primate cortex.

Conclusions:

The described dural-eyelet and artificial dura methods provide reliable solutions for acute Neuropixels probe insertion in primate cortex.
These techniques facilitate advanced neurophysiological studies in awake, behaving non-human primates.
The methods are expected to be valuable for the broader primate neuroscience community.