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SYNAPTOTAGMIN-9 IN MOUSE RETINA
Chris S Mesnard1,2, Cassandra L Hays1,3, Lou E Townsend1,2
1Truhlsen Eye Institute and Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68106, USA.
Biorxiv : the Preprint Server for Biology
|July 10, 2023
Summary
Synaptotagmin-9 (Syt9) is present in the retina and plays a role in visual processing. Eliminating Syt9 from rods impacts retinal signaling, particularly in bright light conditions.
Area of Science:
- Neuroscience
- Ophthalmology
- Molecular Biology
Background:
- Synaptotagmin-9 (Syt9) is a known calcium sensor for fast synaptic release in the brain.
- The expression and function of Syt9 in the retina remain largely uncharacterized.
Conclusions:
- Syt9 is expressed in the retina and influences visual processing.
- Syt9 in rods is critical for regulating visual signaling, particularly under bright light conditions where cone signals are integrated.
- Syt9 may modulate the transmission of cone signals by rod pathways.
