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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Related Experiment Video

Updated: Jul 24, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Causal relationship between gut microbiota and urticaria: a bidirectional two-sample mendelian randomization study.

Yun-Zhou Shi1, Qing-Feng Tao1, Hai-Yan Qin1

  • 1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Frontiers in Microbiology
|July 10, 2023
PubMed
Summary

This study used Mendelian randomization to investigate the causal link between gut microbiota and urticaria. Findings suggest a bidirectional relationship, with specific gut bacteria influencing urticaria risk and vice versa.

Keywords:
Mendelian randomization studybidirectionalcausal relationshipgut microbiotaurticaria

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Area of Science:

  • Microbiome research
  • Genetics
  • Immunology

Background:

  • Emerging evidence links gut microbiota composition to urticaria.
  • The precise causal relationship and its directionality remain unclear.

Purpose of the Study:

  • To establish a causal relationship between gut microbiota and urticaria.
  • To determine if this causal effect is bidirectional.

Main Methods:

  • Utilized genome-wide association studies (GWAS) summary data for 211 gut microbes and urticaria.
  • Employed a bidirectional two-sample Mendelian randomization (MR) analysis.
  • Performed inverse variance weighted (IVW) as the primary method, with MR-Egger, weighted median, and MR-PRESSO for sensitivity analyses.

Main Results:

  • Identified specific gut bacteria associated with increased urticaria risk (e.g., Phylum Verrucomicrobia, Genus Defluviitaleaceae UCG011, Genus Coprococcus 3).
  • Found protective effects from certain bacteria (e.g., Order Burkholderiales, Genus Eubacterium xylanophilum group).
  • Confirmed a causal effect of urticaria on gut microbiota composition (Genus Eubacterium coprostanoligenes group).

Conclusions:

  • Confirmed a potential bidirectional causal relationship between gut microbiota and urticaria.
  • Highlighted specific microbial taxa involved in this relationship.
  • Recommended further research to elucidate underlying mechanisms.