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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

616
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
616
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood Typing01:10

Blood Typing

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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
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The ABO Blood Group01:12

The ABO Blood Group

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The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

360
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Blood Types02:20

Blood Types

17.9K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
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Related Experiment Video

Updated: Jul 24, 2025

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
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Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Published on: November 10, 2023

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ABO blood type incompatible lung transplantation.

Toyofumi F Chen-Yoshikawa1

  • 1Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Journal of Thoracic Disease
|July 10, 2023
PubMed
Summary

ABO-incompatible lung transplants are challenging but feasible, offering hope for patients with end-stage respiratory disease. Successful cases demonstrate that with specific treatments, this method can expand donor options and improve organ allocation fairness.

Keywords:
ABO blood typeABO-incompatiblelung transplantation

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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
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Area of Science:

  • Transplantation immunology
  • Thoracic surgery
  • Immunosuppression protocols

Background:

  • Lung transplantation faces significant challenges due to organ rejection and infection susceptibility.
  • ABO-incompatible (ABOi) transplantation is established for kidney and liver but remains difficult for lungs.
  • Donor organ shortage necessitates exploring ABOi lung transplantation for critically ill patients.

Purpose of the Study:

  • To review worldwide published reports on minor and major ABO-incompatible lung transplantations.
  • To analyze successful strategies and challenges in ABOi lung transplantation.
  • To assess the potential of ABOi lung transplantation in expanding donor pools.

Main Methods:

  • Review of published case reports and studies on ABO-incompatible lung transplantation globally.
  • Analysis of treatment protocols including plasma exchange, immunosuppressive therapy, and antibody depletion.
  • Examination of specific scenarios like clerical errors and hematopoietic stem cell transplantation-induced blood type changes.

Main Results:

  • Major ABOi lung transplants, initially performed due to errors, were successful with enhanced treatment protocols.
  • Successful intentional major ABOi living-donor lobar lung transplants were reported in Japan under specific immunological conditions.
  • Experimental antibody-depletion therapies show promise in overcoming ABO incompatibility.

Conclusions:

  • Despite challenges, ABO-incompatible lung transplantation is a viable option in selected cases.
  • Accumulated evidence supports the development of protocols for intentional ABOi lung transplantation.
  • This approach holds the potential to increase donor organ availability and promote equitable organ allocation.