Related Experiment Video
Updated: Jul 24, 2025
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Monocyte-to-high-density lipoprotein ratio as a predictor for patients with Takayasu arteritis and coronary
Weiping Ci1,2, Jin Wan3, Jing Han1
1Department of Cardiology and Macrovascular Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Insights
The monocyte-to-high-density lipoprotein ratio (MHR) can identify coronary artery involvement in Takayasu arteritis (TAK). Higher MHR levels predict major adverse cardiovascular events in TAK patients, aiding in prognosis.
Area of Science:
- Cardiovascular Medicine
- Inflammatory Diseases
- Biomarker Research
Background:
- The role of the monocyte-to-high-density lipoprotein ratio (MHR) in Takayasu arteritis (TAK) is not well-defined.
- Takayasu arteritis is a large-vessel vasculitis with potential cardiac complications.
Purpose of the Study:
- To evaluate the predictive value of MHR for coronary artery involvement in TAK patients.
- To assess the association between MHR and patient prognosis, including major adverse cardiovascular events (MACEs).
Main Methods:
- Retrospective analysis of 115 TAK patients with coronary angiography.
- Binary logistic and ROC analyses to determine MHR's predictive capability for coronary involvement and left main/three-vessel disease (LMD/3VD).
- 1-year follow-up to assess MACEs using Kaplan-Meier survival analysis, stratified by MHR levels.
Main Results:
- TAK patients with coronary involvement exhibited significantly higher MHR than those without (P=0.014).
- MHR independently predicted coronary involvement (OR: 92.718, P=0.011) and LMD/3VD in TAK.
- An MHR cutoff of 0.35 showed moderate sensitivity and specificity for coronary involvement, significantly improved when combined with other variables. Patients with MHR >0.35 had higher MACE incidence (P=0.029).
Conclusions:
- MHR serves as a practical biomarker for detecting coronary involvement and LMD/3VD in TAK.
- MHR can help predict long-term prognosis and MACE risk in patients with Takayasu arteritis.
Background:
The implication of the monocyte-to-high-density lipoprotein ratio (MHR) in Takayasu arteritis (TAK) remains unclear.
Objective:
We aimed to assess the predictive value of the MHR to identify coronary involvement with TAK and determine the patient prognosis.
Methods:
In this retrospective study, 1,184 consecutive patients with TAK were collected and assessed, and those who were initially treated and with coronary angiography were enrolled and classified according to coronary involvement or no involvement. Binary logistic analysis was performed to assess coronary involvement risk factors. Receiver-operating characteristic analysis was used to determine the MHR value to predict coronary involvement in TAK. Major adverse cardiovascular events (MACEs) were recorded in patients with TAK and coronary involvement within a 1-year follow-up, and Kaplan-Meier survival curve analysis was conducted to compare MACEs between them stratified by the MHR.
Results:
A total of 115 patients with TAK were included in this study, and 41 of them had coronary involvement. A higher MHR was found for TAK with coronary involvement than for TAK without coronary involvement (P = 0.014). Multivariate analysis showed that the MHR is an independent risk factor for coronary involvement in TAK (odds ratio: 92.718, 95% confidence interval (CI): 2.813-3056.291, P = 0.011). With the best cut-off value of 0.35, the MHR identified coronary involvement with 53.7% sensitivity and 68.9% specificity [area under the curve (AUC): 0.639, 95% CI: 0.544-0.726, P=0.010] and identified left main disease and/or three-vessel disease (LMD/3VD) with 70.6% sensitivity and 66.3% specificity (AUC: 0.704, 95% CI: 0.612-0.786, P = 0.003) in TAK. Combined with other variables, the MHR identified coronary involvement with 63.4% sensitivity and 90.5% specificity (AUC: 0.852, 95% CI: 0.773-0.911, P < 0.001), and identified LMD/3VD with 82.4% sensitivity and 78.6% specificity (AUC: 0.827, 95% CI: 0.720-0.934, P < 0.001) in TAK. A total of 39 patients with TAK and coronary involvement were followed up for 1 year, and 5 patients suffered a MACE. Those with an MHR >0.35 had a higher MACE incidence than their counterparts with an MHR ≤0.35 (χ2 = 4.757, P = 0.029).
Conclusions:
The MHR could be a simple, practical biomarker for identifying coronary involvement and LMD/3VD in TAK and predicting a long-term prognosis.
More Related Videos
10:03Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
09:41Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
Published on: October 17, 2017
Related Concept Videos
01:26Coronary Artery Disease IV: Preventive Measures
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:30Coronary Artery Disease I: Introduction