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Inflammation in multiple system atrophy.

Marta Leńska-Mieciek1, Natalia Madetko-Alster2, Piotr Alster2

  • 1Department of Neurology and Epileptology, Centre of Postgraduate Medical Education, Warsaw, Poland.

Frontiers in Immunology
|July 10, 2023
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Summary

Neuroinflammation is central to synucleinopathies and tauopathies, like Parkinsonian syndromes. Targeting inflammation may offer new therapeutic strategies and diagnostic biomarkers for these neurodegenerative diseases.

Keywords:
inflammationmultiple system atrophy (MSA)neurodegenerationsynucleinopathiestauopathies

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Area of Science:

  • Neuroscience
  • Pathology
  • Immunology

Background:

  • Protein misfolding and aggregation are key pathological features of neurodegenerative diseases.
  • Synucleinopathies (e.g., Parkinson's disease) and tauopathies are characterized by alpha-synuclein or tau protein accumulation, respectively.
  • Current therapies do not halt the progression of these proteinopathies.

Purpose of the Study:

  • To review the role of inflammation in the pathogenesis of multiple systems atrophy (MSA).
  • To explore the utility of inflammatory biomarkers in the diagnosis of Parkinsonian syndromes.
  • To discuss potential anti-inflammatory treatment strategies for MSA.

Main Methods:

  • Literature review focusing on inflammation in neurodegeneration.
  • Analysis of studies on alpha-synuclein and tau proteinopathies.
  • Examination of research on multiple systems atrophy pathogenesis and biomarkers.

Main Results:

  • Inflammation plays a significant role in the progression of neurodegenerative diseases like MSA.
  • Inflammatory biomarkers show potential for differential diagnosis among Parkinsonian syndromes.
  • Targeting neuroinflammation presents a promising therapeutic avenue.

Conclusions:

  • Neuroinflammation is a critical factor in MSA pathogenesis.
  • Inflammatory markers may aid in distinguishing between different Parkinsonian syndromes.
  • Modulating the inflammatory response offers a potential therapeutic strategy for synucleinopathies and tauopathies.