Abnormal preoperative leukocyte counts and postoperative complications following total shoulder arthroplasty

Total shoulder arthroplasty (TSA) has become the mainstay of treatment for degenerative glenohumeral arthritis, proximal humerus fracture, and rotator cuff arthropathy. The expanding indications for reverse TSA have increased the overall demand for TSA. This necessitates higher quality preoperative testing and risk stratification. White blood cell counts can be obtained from routine preoperative complete blood count testing. The association between abnormal preoperative white blood cell counts and postoperative complications has not been extensively studied. The purpose of this study was to investigate the association between abnormal preoperative leukocyte counts and 30-day postoperative complications following TSA.

The American College of Surgeons National Surgical Quality Improvement Program database was queried for all patients who underwent TSA between 2015-2020. Patient demographics, comorbidities, surgical characteristics, and 30-day postoperative complication data were collected. Multivariate logistic regression was used to identify postoperative complications associated with preoperative leukopenia and leukocytosis.

In this study, 23,341 patients were included: 20,791 (89.1%) were in the normal cohort, 1307 (5.6%) were in the leukopenia cohort, and 1243 (5.3%) were in the leukocytosis cohort. Preoperative leukopenia was significantly associated with higher rates of bleeding transfusions (P = .011), deep vein thrombosis (P = .037), and non-home discharge (P = .041). After controlling for significant patient variables, preoperative leukopenia was independently associated with higher rates of bleeding transfusions (odds ratios [OR] 1.55, 95% confidence intervals [CI] 1.08-2.23; P = .017) and deep vein thrombosis (OR 2.26, 95% CI 1.07-4.78; P = .033). Preoperative leukocytosis was significantly associated with higher rates of pneumonia (P < .001), pulmonary embolism (P = .004), bleeding transfusions (P < .001), sepsis (P = .007), septic shock (P < .001), readmission (P < .001), and non-home discharge (P < .001). After controlling for significant patient variables, preoperative leukocytosis was independently associated with higher rates of pneumonia (OR 2.20, 95% CI 1.30-3.75; P = .004), pulmonary embolism (OR 2.43, 95% CI 1.17-5.04; P = .017), bleeding transfusions (OR 2.00, 95% CI 1.46-2.72; P < .001), sepsis (OR 2.95, 95% CI 1.20-7.25; P = .018), septic shock (OR 4.91, 95% CI 1.38-17.53; P = .014), readmission (OR 1.36, 95% CI 1.03-1.79; P = .030), and non-home discharge (OR 1.61, 95% CI 1.35-1.92; P < .001).

Preoperative leukopenia is independently associated with higher rates of deep vein thrombosis within 30 days following TSA. Preoperative leukocytosis is independently associated with higher rates of pneumonia, pulmonary embolism, bleeding transfusion, sepsis, septic shock, readmission, and non-home discharge within 30 days following TSA. Understanding the predictive value of abnormal preoperative lab values will aid in perioperative risk stratification and minimize postoperative complications.