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Innovations in cell therapy in pediatric diseases: a narrative review
Razan El Sayed1,2,3, Karan Michael Shankar3, Atharwa Rajan Mankame3
1Department of Pediatric Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.
Translational Pediatrics
|July 10, 2023
Summary
Stem cell therapy shows promise for pediatric diseases, improving outcomes and quality of life. Further research is needed to optimize its implementation and expand clinical trials for pediatric patients.
Area of Science:
- Regenerative Medicine
- Pediatric Therapeutics
- Tissue Engineering
Background:
- Stem cell therapy offers a regenerative approach to treat pediatric diseases by promoting tissue repair and modulating inflammation.
- The number of clinical trials for stem cell therapy in children is increasing, driving advancements in the field.
- Various stem cell types and sources are being explored for their therapeutic potential in pediatric conditions.
Purpose of the Study:
- To review preclinical and clinical stem cell therapy trials in pediatric patients.
- To discuss diverse stem cell types and their applications in pediatric diseases.
- To highlight outcomes and advancements in pediatric stem cell therapy.
Main Methods:
- Searched PubMed and clinicaltrials.gov databases up to October 28, 2022.
- Used MeSH terms 'stem cell' or 'stem cell therapy' with an age filter for individuals under 18 years.
- Included publications from 2000 to 2022.
Main Results:
- Different stem cell sources possess unique properties enabling tailored disease-specific applications.
- Stem cell therapies have demonstrated improved clinical outcomes and quality of life in certain pediatric diseases.
- These therapies present a viable alternative to existing treatment options for pediatric conditions.
Conclusions:
- Stem cell therapy for pediatric diseases yields promising results.
- Further research is essential to determine optimal implementation strategies and treatment timelines.
- Increased preclinical and clinical trials are necessary to advance therapeutic applications in pediatric patients.
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