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Ventricular coupling in constrictive pericarditis.

W P Santamore, R Bartlett, S J Van Buren

    Circulation
    |September 1, 1986
    PubMed
    Summary
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    Constrictive pericarditis significantly increases the coupling between heart ventricles. This enhanced ventricular interdependence helps explain clinical signs and symptoms associated with this condition.

    Area of Science:

    • Cardiology
    • Physiology
    • Pathophysiology

    Background:

    • The ventricles' close anatomic proximity allows for interdependence.
    • Reduced pericardial compliance in disease states is hypothesized to accentuate this coupling.

    Purpose of the Study:

    • To investigate the hypothesis that constrictive pericarditis augments ventricular coupling.
    • To quantify the effect of constrictive pericarditis on pressure-volume relationships between the ventricles.

    Main Methods:

    • Constrictive pericarditis was induced in six dogs via irritant injection.
    • Hearts were subsequently isolated, and balloons were used to measure ventricular pressure and volume changes.
    • Measurements were compared to a control group of four dogs.

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    Main Results:

    • Ventricular coupling was significantly augmented in dogs with constrictive pericarditis.
    • Changes in ventricular pressure and volume due to contralateral changes were significantly greater (p < .05) in the constrictive pericarditis group.
    • This indicates heightened interdependence between the ventricles.

    Conclusions:

    • Constrictive pericarditis leads to increased coupling between the cardiac ventricles.
    • This finding provides a physiological explanation for observed signs and symptoms of constrictive pericarditis.