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Updated: Jul 24, 2025

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
Published on: November 22, 2016
Tertiary Amine-Mediated Reductions of Phosphine Oxides to Phosphines
Keshu Yin1, Mingjie Wei2, Zhenguo Wang1
1PCFM Lab and GDHPRC Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, P. R. China.
Abstract:
The reduction of phosphine oxides without the use of highly reactive reductants represents a safer and more sustainable solution for recycling of organophosphorus compounds. Herein, we disclose an N,N,N',N'-tetramethylethylenediamine (TMEDA)-mediated reduction via an unusual intermolecular hydride transfer. Mechanistic studies suggest that TMEDA serves as a hydride donor, while the P(V) halophosphonium salt acts as the hydride acceptor. This methodology provides a scalable and efficient protocol to reduce phosphine oxides under mild conditions.
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